Kava kava
Update: 2015/3/26 View:
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Introduction
| 30% Kavalactones －HPLC | |||||||||||
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Kava (Piper methysticum)
Description:
Kava is a member of the pepper family and is native to many Pacific Ocean islands. The root stock is most often used for herbal remedies. Currently, pharmaceutical preparations of the herb are widely used in Europe and the United States for anxiety. However, they have recently been withdrawn from several European markets due to safety concerns and many reports of severe liver damage.
Claims:
Safety:
Aviod if allergic to kava or kavapyrones. Avoid if history of liver disease, Parkinson's disease, heart disease, lung disease, eye disease, depression, bipolar disease or blood cell disorders. Avoid while driving or operating heavy machinery (may cause drowsiness). Avoid if pregnant or breastfeeding.
Possible side effects:
Abnormal muscle movements, acute urinary retention, allergic rash, anorexia, apathy, bleeding, blood cell abnormalities, electrocardiogram (ECG) abnormalities, enhanced or decreased cognitive performance, eye irritation, increased blood pressure in the lungs (pulmonary hypertension), kidney damage, liver damage/failure (severe in multiple reported cases in Europe and the Americas), mild headache, mood elevation, paresthesia, palpitations, rapid heart rate, seizures, sedation (drowsiness), shortness of breath, skin disorders, sleeplessness, stomach upset.
Possible interactions:
Blood thinning drugs or drugs that increase the risk of bleeding (warfarin ), pain relief drugs, PC-SPES?(contains saw palmetto and seven other herbs, currently taken off the U.S. market), male sex hormones, birth control pills, hormone replacement therapy (HRT), estrogens, alcohol, and herbs and supplements with similar effects (like red clover, ginkgo biloba and garlic). Many tinctures contain high levels of alcohol and may cause nausea or vomiting when taken with prescription drugs like metronidazole or disulfiram.
Dosing:
Kava extract is typically standardized to 30% kava lactones. Many brands use the standardized preparation WS 1490. A review of standardized kava brands in the United States found 50-110 milligrams kava lactones per tablet/capsule.
Adults (18 years and older):
Kava Extract: 50-100 milligrams has been taken by mouth for up to two months
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