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Melatonin

Update: 2015/4/16      View:
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Introduction
95~98% -HPLC
 
 
Melatonin
 
Description:
 
Melatonin is a neurohormone produced in the brain. Levels of melatonin in the blood are highest prior to bedtime. Melatonin products have been used for a many medical conditions. It is most often used for people who have trouble sleeping (insomnia).
 

Claims:

Uses

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Grade*

Jet lag

A

Delayed sleep phase syndrome (DSPS), Sleep enhancement in healthy people

B

Sleep disturbances in children with neuro-psychiatric disorders, Insomnia in the elderly

B

Alzheimer's disease (sleep disorders), Antioxidant, Attention deficit hyperactivity disorder (ADHD)

C

Benzodiazepine tapering, Bipolar disorder (sleep disturbances), Cancer treatment, Glaucoma

C

Chemotherapy side effects, Circadian rhythm entraining (in blind persons), Parkinson's disease

C

Headache prevention, High blood pressure, HIV/AIDS, Schizophrenia (sleep disorders)

C

Insomnia (of unknown origin in the non-elderly), Irritable bowel syndrome (IBS)

C

Periodic limb movement disorder, REM sleep behavior disorder, Seasonal affective disorder (SAD)

C

Rett syndrome, Sedation before surgery/anxiety, Seizure disorder (children),

C

Sleep disturbances due to pineal region brain damage, Thrombocytopenia (low platelets)

C

Sleep in asthma sufferers, Depression (sleep disturbances), Tardive dyskinesia

C

Smoking, Ultraviolet light skin damage protection, Work shift sleep disorder, Stroke

C

*Key to gradesA: Strong scientific evidence for this use; B: Good scientific evidence for this use; C: Unclear scientific evidence for this use; D: Fair scientific evidence against this use (it may not work); F: Strong scientific evidence against this use (it likely does not work).




Possible side effects:
Blood clotting abnormalities (particularly in patients taking blood thinners like warfarin), increased risk of seizure, disorientation, fatigue, dizziness, headache, irritability, sleepiness, confusion, sleepwalking, vivid dreams and nightmares, nausea, vomiting, cramping, changes in blood pressure, increased cholesterol, increased blood sugar, reduced glucose tolerance, reduced insulin sensitivity, hallucinations, paranoia, hormonal changes, increased breast size in men, reduced sperm motility, mood changes, abnormal heart rhythms, chest pain, liver inflammation (autoimmune hepatitis), triggering of Crohn's disease symptoms.
 
Possible interactions:
Drugs broken down by the liver, sedative drugs (like Ambien®), barbiturates, narcotics, antidepressants, alcohol, drugs that increase the risk of bleeding like warfarin (Coumadin®), anticoagulants (like aspiring or heparin), non-steroidal anti-inflammatories (like ibuprofen), naproxen (Naprosyn®, Aleve®), drugs that affect blood pressure (like atenolol), drugs that lower levels of vitamin B6 in the body (like birth control pills, hormone replacement therapy or loop diuretics), diazepam, verapamil, temazepam, somatostatin, drugs that alter blood sugar levels, (like insulin), caffeine, succinylcholine, methamphetamine, isoniazid, herbs or supplements with similar effects (like 5-HTP, Ginkgo biloba, garlic, saw palmetto, vitamin B12, chasteberry, arginine, DHEA, Echinacea).
 
Dosing:
Adults (18 years and older):
0.1 to 50mg has been taken by mouth. Please consult your doctor and pharmacist before taking melatonin.
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